Trouvé à l'intérieur – Page 887Equivalent simvastatin scribed antihypertensive medication in addition to their cholesterol- dosages were calculated by dividing lovastatin and pravastatin ... Trouvé à l'intérieur – Page 257A comparison of the efficacy and safety of simvastatin and pravastatin in the treatment of hypercholesterolemia . ... that the package inserts for pravastatin , lovastatin , and simvastatin are similar with regard to warfarin drug interactions . Trouvé à l'intérieur – Page 17For example, in a comparison between simvastatin, the most lipophilic statin, and pravastatin the most hydrophilic statin, the former showed a significantly ... Trouvé à l'intérieur – Page 8... pravastatin , simvastatin LDL - cholesterol - 20-40 percent HDL - cholesterol ... All three available statins appear to have similar efficacy when ... Trouvé à l'intérieur – Page 434Mice were injected with an equal volume of vehicle, simvastatin, or pravastatin 18 hours prior to the initiation of coronary occlusion and reperfusion. Trouvé à l'intérieur – Page 306Pharmacokinetic Properties of Lovastatin, Pravastatin, and Simvastatin ... similar binding of cholestyramine to lovastatin and simvastatin does not appear ... Trouvé à l'intérieur – Page 145Comparable doses: Lovastatin 40 mg = Pravastatin 40 mg = Simvastatin 20 mg = Comparable doses: Lovastatin 40 mg = Pravastatin 40 mg = Simvastatin 20 mg ... Trouvé à l'intérieur – Page 591Lovastatin and simvastatin are neutral, lactone pro-drugs and should be classified as nonelecLrolyles. Pravastatin, fluvastatin, and atorvastatin can be ... Trouvé à l'intérieur – Page 488Similar changes were observed in the group treated with pravastatin . After 4 ... lipid bilayer at this depth is altered in type 2 hypercholesterolemia erythrocytes , but during simvastatin and pravastatin therapy these changes are partly reversed . Simvastatin; - the Scandinavian Simvastatin Survival Study (4S) and the Heart Protection Study (HPS) - confirmed reductions in CHD events as well as all-cause mortality and showed no increase in non-cardiovascular mortality or cancer in the ... Trouvé à l'intérieur – Page 1214Simvastatin NTE 10 mg/day Lovastatin NTE 40 mg/day Amlodipine Simvastatin NTE ... Avoidance or use of alternative therapies such as pravastatin, atenolol, ... Trouvé à l'intérieur – Page 263... CHD Risk Equivalent Patients 4S87 Simvastatin 20–40 mg 188 (117) ↓35 21.8 ↓34 LIPID88 Pravastatin 40 mg 150 (112) ↓25 15.9 ↓24 CARE89 Pravastatin 40 ... Trouvé à l'intérieur – Page 154... give you the equivalent effect: 10 mg atorvastatin (Lipitor) 20 mg simvastatin (Zocor) 40 mg pravastatin (Pravachol) 40 mg lovastatin (Mevacor, Altocor; ... Trouvé à l'intérieur – Page 157In a replication cohort of patients who received simvastatin 40 mg/day as ... simvastatin dose or considering an alternative statin (e.g., pravastatin or ... Unlike much work in this area, Copayments and the Demand for Prescription Drugs is not sponsored by any drug company; and its up-to-date results, established on a firm scientific basis, are entirely unbiased. Trouvé à l'intérieur – Page 418Pravastatin (Pravachol, Lipostat) In the primary prevention WOSCOPS trial, pravastatin ... Cautions and contraindications are also similar to other statins. Trouvé à l'intérieur – Page 547In one series, the frequency of liver toxicity was similar in patients taking pravastatin or simvastatin (30), while in another study there was a difference ... Trouvé à l'intérieurFMD increased in the pravastatin treatment group but not in the control group. ... treatments that obtain equivalent LDL-c reductions (80 mg of simvastatin, ... Trouvé à l'intérieur – Page 10The best course of action is to discontinue pravastatin and initiate therapy with another statin . The choice of statin is based on the chemical structures . The simvastatin molecule is similar to pravastatin except that it contains a methyl group in ... Trouvé à l'intérieur – Page 415Simvastatin is a semi-synthetic derivative of lovastatin, whereas atorvastatin ... but has been used in Japan since 2003.65 It is similar to pravastatin and ... Trouvé à l'intérieur – Page 277... proven efficacy in randomized trials (such as pravastatin and simvastatin). ... The overall adverse-event profile was similar to that observed for other ... Trouvé à l'intérieur – Page 69Interestingly , individuals who were randomly assigned to pravastatin in the ... Simvastatin also seems to be able to confer similar protection to heart ... Trouvé à l'intérieur – Page 984Pravastatin is active alone and is not metabolized by CYP3A. ... The interaction of diltiazem with simvastatin has been investigated in 135 patients ... Trouvé à l'intérieur – Page 44Gemfibrozil increased rosuvastatin plasma concentrations approximately 2 - fold , which is similar to the effect of gemfibrozil on pravastatin , simvastatin ... Trouvé à l'intérieur – Page 578... Mean Percentage Changes from Baseline (%) Atorvastatin Cerivastatin Fluvastatin Lovastatin Pravastatin Simvastatin ... perivascular hemorrhage, edema, mononuclear cell infiltration of perivascular spaces and other similar CNS vascular ... Trouvé à l'intérieur – Page 150Recently, similar results were reported from the Multicentre Anti-Atheroma ... either pravastatin or simvastatin at doses adjusted to produce equivalent ... This volume features evidence-based discussion on the indications, pharmacokinetics, and safety profiles of the available statins and how these properties translate into selection of the appropriate treatment regimen for the individual ... Trouvé à l'intérieur – Page 887The absorption and metabolism of lovastatin and simvastatin are similar (see Appendix II). In animals approximately 30% of an oral dose of ... Pravastatin is administered in its active form as a sodium salt. Approximately 34% of an oral dose is ... Trouvé à l'intérieur – Page 114Subgroup analysis suggested that simvastatin therapy produced similar reductions in ... The Prospective Study of Pravastatin in the Elderly at Risk trial63 ... Trouvé à l'intérieurSimilar data on simvastatin, pravastatin and fluvastatin are not available. HMG-CoA reductase inhibitors are initially given in a single dose with the evening meal or at bedtime to take advantage of the fact that more cholesterol synthesis takes ... Trouvé à l'intérieur – Page 291The first generation statins (lovastatin, pravastatin, and simvastatin) are structurally similar and are derived as metabolites from fungal cultures.